{"@context":"http://iiif.io/api/presentation/2/context.json","@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/manifest.json","@type":"sc:Manifest","label":"Model Compounds for the Biomimetic Synthesis of Gukulenins","metadata":[{"label":"dc.description.sponsorship","value":"This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree"},{"label":"dc.format","value":"Monograph"},{"label":"dc.format.medium","value":"Electronic Resource"},{"label":"dc.identifier.uri","value":"http://hdl.handle.net/11401/78195"},{"label":"dc.language.iso","value":"en_US"},{"label":"dcterms.abstract","value":"Gukulenin A, a tetraterpene, contains a unique bis-tropolone moiety, and exhibits potent cytotoxicity against various cell lines (human pharynx cancer FaDu, colon cancer HCT-116, renal cancer SN12C, stomach cancer MKN45). Developing a straightforward and concise synthesis of gukulenin A from easily available starting materials is meaningful for synthetic chemistry as well as drug discovery. In our research, we proposed that gukulenin A could be assembled via the four types of dimerization from three different substrates. In this project, we focused on the synthesis of 4-methyltropolone as the substrate for oxidative coupling, and (Z)-1-oxo-1-phenylpenta-2,4-dien-2-yl acetate as the model for a new Michael addition approach. At this point, we have obtained 4-methyltropolone with one of its isomers, and we have successfully made (Z)-1-oxo-1-phenylpenta-2,4-dien-2-yl acetate and tested the Michael-type dimerization under basic condition."},{"label":"dcterms.available","value":"2018-03-22T22:39:17Z"},{"label":"dcterms.contributor","value":"Ngai, Ming-Yu"},{"label":"dcterms.creator","value":"Su, Siyuan"},{"label":"dcterms.dateAccepted","value":"2018-03-22T22:39:17Z"},{"label":"dcterms.dateSubmitted","value":"2018-03-22T22:39:17Z"},{"label":"dcterms.description","value":"Department of Chemistry."},{"label":"dcterms.extent","value":"61 pg."},{"label":"dcterms.format","value":"Application/PDF"},{"label":"dcterms.identifier","value":"http://hdl.handle.net/11401/78195"},{"label":"dcterms.issued","value":"2017-08-01"},{"label":"dcterms.language","value":"en_US"},{"label":"dcterms.provenance","value":"Made available in DSpace on 2018-03-22T22:39:17Z (GMT). No. of bitstreams: 1\nSu_grad.sunysb_0771M_13385.pdf: 5007879 bytes, checksum: 7bc074ff544c8c032053866a29d8c5d6 (MD5)\n  Previous issue date: 2017-08-01"},{"label":"dcterms.subject","value":"Model study"},{"label":"dcterms.title","value":"Model Compounds for the Biomimetic Synthesis of Gukulenins"},{"label":"dcterms.type","value":"Thesis"},{"label":"dc.type","value":"Thesis"}],"description":"This manifest was generated dynamically","viewingDirection":"left-to-right","sequences":[{"@type":"sc:Sequence","canvases":[{"@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/canvas/page-1.json","@type":"sc:Canvas","label":"Page 1","height":1650,"width":1275,"images":[{"@type":"oa:Annotation","motivation":"sc:painting","resource":{"@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/13%2F22%2F77%2F132277141562999956201340808608420648237/full/full/0/default.jpg","@type":"dctypes:Image","format":"image/jpeg","height":1650,"width":1275,"service":{"@context":"http://iiif.io/api/image/2/context.json","@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/13%2F22%2F77%2F132277141562999956201340808608420648237","profile":"http://iiif.io/api/image/2/level2.json"}},"on":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/canvas/page-1.json"}]}]}]}