{"@context":"http://iiif.io/api/presentation/2/context.json","@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/manifest.json","@type":"sc:Manifest","label":"Clinically Translating Contrast-Enhanced X-ray Breast Imaging","metadata":[{"label":"dc.description.sponsorship","value":"This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree"},{"label":"dc.format","value":"Monograph"},{"label":"dc.format.medium","value":"Electronic Resource"},{"label":"dc.identifier.uri","value":"http://hdl.handle.net/11401/78187"},{"label":"dc.language.iso","value":"en_US"},{"label":"dcterms.abstract","value":"Contrast-enhanced digital mammography (CEDM) and digital breast tomosynthesis (CEDBT) are radiographic breast imaging techniques currently being investigating to improve the diagnosis of breast cancer. While initial studies of these methods have shown promising results, the techniques remain nascent and are immature for clinical adoption. This work aims to address problems at several stages of the clinical translational pathway. Methods and metrics to evaluate performance and consistency of digital breast tomosynthesis (DBT) for clinical imaging and contrast-enhanced applications are developed. Since no standardized procedures for measuring spatial resolution in DBT have yet been established, various methods for characterizing spatial/axial resolution are investigated. Separately, a geometrical calibration phantom and procedure for DBT are developed and used to study system stability necessary for dual-energy CEDBT, in which a low- and a high-energy scan must be acquired under identical geometry. Improvements to mammographic x-ray detector performance are investigated for low-dose imaging, necessary for DBT, and dual-energy imaging, a practical realization of contrast-enhanced breast imaging. A novel technology capable of avalanche gain and equipped with high-resolution field emitter array readout is investigated for low-dose imaging. Independently, a more mature detector technology, the amorphous selenium direct-conversion flat-panel imager, is evolved for dual-energy breast imaging applications. A prototype detector is fabricated and its imaging performance investigated. Imaging techniques are developed and evaluated to reduce requisite breast compression to facilitate contrast medium perfusion in the breast. Using a signal-difference-to-noise ratio (SDNR) model accounting for the increase in scatter radiation due to increased effective breast thickness, an imaging technique is developed that maintains SDNR without increasing mean glandular dose. Several practical aspects of the implementation of dual-energy CEDM and CEDBT protocols are considered. Finally, the feasibility of CEDM and CEDBT for improved breast cancer diagnosis is demonstrated in two clinical studies. The diagnostic performance these techniques is assessed by imaging 25 patients and comparing imaging findings with histopathology. Performance of CEDM and CEDBT are compared for lesion enhancement and margin delineation. Image subtraction strategies for CEDBT are investigated for optimal lesion enhancement and relative contrast agent quantification."},{"label":"dcterms.available","value":"2018-03-22T22:39:15Z"},{"label":"dcterms.contributor","value":"Zhao, Wei."},{"label":"dcterms.creator","value":"Scaduto, David Anthony"},{"label":"dcterms.dateAccepted","value":"2018-03-22T22:39:15Z"},{"label":"dcterms.dateSubmitted","value":"2018-03-22T22:39:15Z"},{"label":"dcterms.description","value":"Department of Biomedical Engineering."},{"label":"dcterms.extent","value":"198 pg."},{"label":"dcterms.format","value":"Application/PDF"},{"label":"dcterms.identifier","value":"http://hdl.handle.net/11401/78187"},{"label":"dcterms.issued","value":"2017-08-01"},{"label":"dcterms.language","value":"en_US"},{"label":"dcterms.provenance","value":"Made available in DSpace on 2018-03-22T22:39:15Z (GMT). No. of bitstreams: 1\nScaduto_grad.sunysb_0771E_13369.pdf: 13913108 bytes, checksum: f27b9aa7996f647289325d259cf06c25 (MD5)\n  Previous issue date: 2017-08-01"},{"label":"dcterms.subject","value":"digital breast tomosynthesis"},{"label":"dcterms.title","value":"Clinically Translating Contrast-Enhanced X-ray Breast Imaging"},{"label":"dcterms.type","value":"Dissertation"},{"label":"dc.type","value":"Dissertation"}],"description":"This manifest was generated dynamically","viewingDirection":"left-to-right","sequences":[{"@type":"sc:Sequence","canvases":[{"@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/canvas/page-1.json","@type":"sc:Canvas","label":"Page 1","height":1650,"width":1275,"images":[{"@type":"oa:Annotation","motivation":"sc:painting","resource":{"@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/14%2F34%2F96%2F143496705287982886041904885095593343815/full/full/0/default.jpg","@type":"dctypes:Image","format":"image/jpeg","height":1650,"width":1275,"service":{"@context":"http://iiif.io/api/image/2/context.json","@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/14%2F34%2F96%2F143496705287982886041904885095593343815","profile":"http://iiif.io/api/image/2/level2.json"}},"on":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/canvas/page-1.json"}]}]}]}