{"@context":"http://iiif.io/api/presentation/2/context.json","@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/manifest.json","@type":"sc:Manifest","label":"In Situ Chemically Crosslinked Carbon Nanomaterial Coatings and Films for Tissue Engineering Applications","metadata":[{"label":"dc.description.sponsorship","value":"This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree."},{"label":"dc.format","value":"Monograph"},{"label":"dc.format.medium","value":"Electronic Resource"},{"label":"dc.identifier.uri","value":"http://hdl.handle.net/11401/76984"},{"label":"dc.language.iso","value":"en_US"},{"label":"dc.publisher","value":"The Graduate School, Stony Brook University: Stony Brook, NY."},{"label":"dcterms.abstract","value":"A current limitation in translating nanotechnology research into the many industries is the assembly of the nanostructural building blocks into complex 2D or 3D structures. Although carbon nanomaterials have shown a great deal of prospect in biomedical engineering, this limitation strongly hinders many translatable biomedical applications for these materials. Weak bonding between the nanoparticles can lead to loose nanomaterial related toxicity and the lack of robustness in devices. In this work we developed a facile and scalable method to develop chemically crosslinked carbon nanomaterial thin films and coatings for biomedical applications. We developed crosslinked coatings of carbon nanotubes and graphene of different diameters and lengths. We present the in vitro cytocompatibility and stem cell differentiation capability of these coatings using human adipose derived stem cells. Our results indicate little or no cellular toxicity on these coatings. We also observed nanoparticle size and chemistry related dependence on the ability for stem cells to differentiate towards osteogenic lineages on these coatings. The results suggest potential for these coatings as surfaces for enhanced osseointegration in orthopedic applications."},{"label":"dcterms.available","value":"2017-09-20T16:51:35Z"},{"label":"dcterms.contributor","value":"Brouzes, Eric"},{"label":"dcterms.creator","value":"Patel, Sunny"},{"label":"dcterms.dateAccepted","value":"2017-09-20T16:51:35Z"},{"label":"dcterms.dateSubmitted","value":"2017-09-20T16:51:35Z"},{"label":"dcterms.description","value":"Department of Biomedical Engineering."},{"label":"dcterms.extent","value":"154 pg."},{"label":"dcterms.format","value":"Monograph"},{"label":"dcterms.identifier","value":"http://hdl.handle.net/11401/76984"},{"label":"dcterms.issued","value":"2015-05-01"},{"label":"dcterms.language","value":"en_US"},{"label":"dcterms.provenance","value":"Made available in DSpace on 2017-09-20T16:51:35Z (GMT). No. of bitstreams: 1\nPatel_grad.sunysb_0771E_12596.pdf: 5330989 bytes, checksum: e2ea0ef7e443793edc3fbfa6c0ec5ac8 (MD5)\n  Previous issue date: 2015"},{"label":"dcterms.publisher","value":"The Graduate School, Stony Brook University: Stony Brook, NY."},{"label":"dcterms.subject","value":"Carbon Nanomaterials, Nanotechnology, Tissue Engineering"},{"label":"dcterms.title","value":"In Situ Chemically Crosslinked Carbon Nanomaterial Coatings and Films for Tissue Engineering Applications"},{"label":"dcterms.type","value":"Dissertation"},{"label":"dc.type","value":"Dissertation"}],"description":"This manifest was generated dynamically","viewingDirection":"left-to-right","sequences":[{"@type":"sc:Sequence","canvases":[{"@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/canvas/page-1.json","@type":"sc:Canvas","label":"Page 1","height":1650,"width":1275,"images":[{"@type":"oa:Annotation","motivation":"sc:painting","resource":{"@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/13%2F40%2F50%2F134050976925305938401411046948007309884/full/full/0/default.jpg","@type":"dctypes:Image","format":"image/jpeg","height":1650,"width":1275,"service":{"@context":"http://iiif.io/api/image/2/context.json","@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/13%2F40%2F50%2F134050976925305938401411046948007309884","profile":"http://iiif.io/api/image/2/level2.json"}},"on":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/canvas/page-1.json"}]}]}]}