{"@context":"http://iiif.io/api/presentation/2/context.json","@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/manifest.json","@type":"sc:Manifest","label":"Transcriptional Regulation of MMP-9 and MMP-14 by p53 and its Mutant R280K","metadata":[{"label":"dc.description.sponsorship","value":"This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree."},{"label":"dc.format","value":"Monograph"},{"label":"dc.format.medium","value":"Electronic Resource"},{"label":"dc.identifier.uri","value":"http://hdl.handle.net/11401/76900"},{"label":"dc.language.iso","value":"en_US"},{"label":"dc.publisher","value":"The Graduate School, Stony Brook University: Stony Brook, NY."},{"label":"dcterms.abstract","value":"Breast cancer is the most common cancer in women and metastasis is the primary cause for mortality. Matrix metalloproteinases (MMPs) play important roles in cancer cell migration and invasion. Tumor suppressor gene TP53 is the most frequently mutated gene in cancer, and p53 mutation occurs in invasive breast cancer with higher frequency than in non-invasive breast cancer. However, the nature of relationship between p53 and MMPs remains inconclusive. Here we show that wild type p53 could repress transcriptional activity of MMP-9 and MMP-14, while the DNA-contact mutant p53 R280K could upregulate the transcription of MMP-9 and MMP-14. This regulation might be Sp1-dependent as there is a p53/Sp1 overlapping binding site on the promoters of MMP-9 and MMP-14. Although additional study is needed to further confirm this mechanism, our finding would provide a potential target for anti-metastatic therapy."},{"label":"dcterms.available","value":"2017-09-20T16:51:24Z"},{"label":"dcterms.contributor","value":"Mao, Cungui."},{"label":"dcterms.creator","value":"Xue, Yingjiao"},{"label":"dcterms.dateAccepted","value":"2017-09-20T16:51:24Z"},{"label":"dcterms.dateSubmitted","value":"2017-09-20T16:51:24Z"},{"label":"dcterms.description","value":"Department of Biochemistry and Cell Biology"},{"label":"dcterms.extent","value":"29 pg."},{"label":"dcterms.format","value":"Application/PDF"},{"label":"dcterms.identifier","value":"http://hdl.handle.net/11401/76900"},{"label":"dcterms.issued","value":"2016-12-01"},{"label":"dcterms.language","value":"en_US"},{"label":"dcterms.provenance","value":"Made available in DSpace on 2017-09-20T16:51:24Z (GMT). No. of bitstreams: 1\nXue_grad.sunysb_0771M_13101.pdf: 1229735 bytes, checksum: d646fa0a1db0fd27ec1ac47defcf44b9 (MD5)\n  Previous issue date:    1"},{"label":"dcterms.publisher","value":"The Graduate School, Stony Brook University: Stony Brook, NY."},{"label":"dcterms.subject","value":"Molecular biology"},{"label":"dcterms.title","value":"Transcriptional Regulation of MMP-9 and MMP-14 by p53 and its Mutant R280K"},{"label":"dcterms.type","value":"Thesis"},{"label":"dc.type","value":"Thesis"}],"description":"This manifest was generated dynamically","viewingDirection":"left-to-right","sequences":[{"@type":"sc:Sequence","canvases":[{"@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/canvas/page-1.json","@type":"sc:Canvas","label":"Page 1","height":1650,"width":1275,"images":[{"@type":"oa:Annotation","motivation":"sc:painting","resource":{"@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/42%2F26%2F88%2F42268861505038554507422192381110535674/full/full/0/default.jpg","@type":"dctypes:Image","format":"image/jpeg","height":1650,"width":1275,"service":{"@context":"http://iiif.io/api/image/2/context.json","@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/42%2F26%2F88%2F42268861505038554507422192381110535674","profile":"http://iiif.io/api/image/2/level2.json"}},"on":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/canvas/page-1.json"}]}]}]}