{"@context":"http://iiif.io/api/presentation/2/context.json","@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/manifest.json","@type":"sc:Manifest","label":"A Role for HMGB2 in Mammalian Neurogenesis and Stroke","metadata":[{"label":"dc.description.sponsorship","value":"This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree."},{"label":"dc.format","value":"Monograph"},{"label":"dc.format.medium","value":"Electronic Resource"},{"label":"dc.identifier.uri","value":"http://hdl.handle.net/11401/76574"},{"label":"dc.language.iso","value":"en_US"},{"label":"dc.publisher","value":"The Graduate School, Stony Brook University: Stony Brook, NY."},{"label":"dcterms.abstract","value":"Stroke results in areas of neuronal cell death with concomitant inflammation and edema in the surrounding tissues. Ischemia in the thalamus can present as an accumulation of many smaller lacunar infarcts leading to potential cognitive deficits and central post-stroke pain syndromes, for which curative therapies are lacking. The capacity of the brain to repair itself rests upon the robust response of adult neurogenesis, and gliogenesis, to formidable ischemic conditions. In this study I assess the role chromatin modulator HMGB2 plays in both neurogenesis/gliogenesis and adult thalamic ischemia. Firstly, we demonstrate that this protein can affect the transition between the creation of new neurons and glial cells during development. Secondly, following the induction of stroke in the thalamus, loss of HMGB2 lowers the rate of apoptotic cell death and differentially modulates behavioral outcomes of the ischemic lesion. The numerous intra and extra-cellular roles for HMGB2 in a diverse array of brain functions makes it an important molecule for further study."},{"label":"dcterms.available","value":"2017-09-20T16:50:41Z"},{"label":"dcterms.contributor","value":"Aguirre, Adan"},{"label":"dcterms.creator","value":"Bronstein, Robert"},{"label":"dcterms.dateAccepted","value":"2017-09-20T16:50:41Z"},{"label":"dcterms.dateSubmitted","value":"2017-09-20T16:50:41Z"},{"label":"dcterms.description","value":"Department of Neuroscience."},{"label":"dcterms.extent","value":"153 pg."},{"label":"dcterms.format","value":"Monograph"},{"label":"dcterms.identifier","value":"http://hdl.handle.net/11401/76574"},{"label":"dcterms.issued","value":"2015-12-01"},{"label":"dcterms.language","value":"en_US"},{"label":"dcterms.provenance","value":"Made available in DSpace on 2017-09-20T16:50:41Z (GMT). No. of bitstreams: 1\nBronstein_grad.sunysb_0771E_12332.pdf: 76165272 bytes, checksum: fe91ab9aefdbfa96cd3d9c858bb94b11 (MD5)\n  Previous issue date:    1"},{"label":"dcterms.publisher","value":"The Graduate School, Stony Brook University: Stony Brook, NY."},{"label":"dcterms.subject","value":"Neurosciences"},{"label":"dcterms.title","value":"A Role for HMGB2 in Mammalian Neurogenesis and Stroke"},{"label":"dcterms.type","value":"Dissertation"},{"label":"dc.type","value":"Dissertation"}],"description":"This manifest was generated dynamically","viewingDirection":"left-to-right","sequences":[{"@type":"sc:Sequence","canvases":[{"@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/canvas/page-1.json","@type":"sc:Canvas","label":"Page 1","height":1650,"width":1275,"images":[{"@type":"oa:Annotation","motivation":"sc:painting","resource":{"@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/11%2F05%2F76%2F110576040507525766507844420130110132558/full/full/0/default.jpg","@type":"dctypes:Image","format":"image/jpeg","height":1650,"width":1275,"service":{"@context":"http://iiif.io/api/image/2/context.json","@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/11%2F05%2F76%2F110576040507525766507844420130110132558","profile":"http://iiif.io/api/image/2/level2.json"}},"on":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/canvas/page-1.json"}]}]}]}