{"@context":"http://iiif.io/api/presentation/2/context.json","@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/manifest.json","@type":"sc:Manifest","label":"Hybrid Nanostructures for Bone Tissue Engineering","metadata":[{"label":"dc.description.sponsorship","value":"This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree."},{"label":"dc.format","value":"Monograph"},{"label":"dc.format.medium","value":"Electronic Resource"},{"label":"dc.identifier.uri","value":"http://hdl.handle.net/11401/72712"},{"label":"dc.language.iso","value":"en_US"},{"label":"dc.publisher","value":"The Graduate School, Stony Brook University: Stony Brook, NY."},{"label":"dcterms.abstract","value":"Natural bone is composed of natural polymers, collagen fibers and nano-crystals of minerals, mainly nano-hydroxyapatite (HA). Bone cells, which maintain the activities and metabolism of bone, are supported by and interact with this organic-inorganic hybrid matrix. Artificial bone tissue scaffolds mimicking the natural bone's extracellular matrix based on synthetic hybrid cellulose acetate (CA)-hydroxyapatite nano-composites were fabricated in this work in 3D matrix architecture for bone cell regeneration, using a single step nano-manufacturing technique. Cultured human osteoblasts were seeded on CA and CA-HA scaffolds, after which cell proliferative capacity and viability were studied using complementary assays. The interactions between the cells and the scaffolds were further characterized by scanning electron microscopy (SEM). Osteoblasts grown on these scaffolds appear to interact strongly with nano-HA clusters, resulting in cell growth and phenotype retention. The hybrids scaffolds used are shown to be ideal bone repair agents."},{"label":"dcterms.available","value":"2015-04-24T14:53:19Z"},{"label":"dcterms.contributor","value":"Tadanori Koga"},{"label":"dcterms.creator","value":"Xue, Ruipeng"},{"label":"dcterms.dateAccepted","value":"2015-04-24T14:53:19Z"},{"label":"dcterms.dateSubmitted","value":"2015-04-24T14:53:19Z"},{"label":"dcterms.description","value":"Department of Materials Science and Engineering"},{"label":"dcterms.format","value":"Application/PDF"},{"label":"dcterms.identifier","value":"http://hdl.handle.net/1951/55676"},{"label":"dcterms.issued","value":"2010-05-01"},{"label":"dcterms.language","value":"en_US"},{"label":"dcterms.provenance","value":"Made available in DSpace on 2012-05-15T18:07:23Z (GMT). No. of bitstreams: 1\nXue_grad.sunysb_0771M_10129.pdf: 5128971 bytes, checksum: c41df1948e2cbc2cef6f0a5f208d7987 (MD5)\n  Previous issue date:    1"},{"label":"dcterms.publisher","value":"The Graduate School, Stony Brook University: Stony Brook, NY."},{"label":"dcterms.subject","value":"Engineering, Materials Science"},{"label":"dcterms.title","value":"Hybrid Nanostructures for Bone Tissue Engineering"},{"label":"dcterms.type","value":"Thesis"},{"label":"dc.type","value":"Thesis"}],"description":"This manifest was generated dynamically","viewingDirection":"left-to-right","sequences":[{"@type":"sc:Sequence","canvases":[{"@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/canvas/page-1.json","@type":"sc:Canvas","label":"Page 1","height":1650,"width":1275,"images":[{"@type":"oa:Annotation","motivation":"sc:painting","resource":{"@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/36%2F83%2F26%2F36832688761688062050081809875045820880/full/full/0/default.jpg","@type":"dctypes:Image","format":"image/jpeg","height":1650,"width":1275,"service":{"@context":"http://iiif.io/api/image/2/context.json","@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/36%2F83%2F26%2F36832688761688062050081809875045820880","profile":"http://iiif.io/api/image/2/level2.json"}},"on":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/canvas/page-1.json"}]}]}]}