{"@context":"http://iiif.io/api/presentation/2/context.json","@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/manifest.json","@type":"sc:Manifest","label":"Design, synthesis and biological \nevaluation of new-generation taxoid-based tumor-targeting drug conjugates","metadata":[{"label":"dc.description.sponsorship","value":"This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree."},{"label":"dc.format","value":"Monograph"},{"label":"dc.format.medium","value":"Electronic Resource"},{"label":"dc.identifier.uri","value":"http://hdl.handle.net/1951/59941"},{"label":"dc.language.iso","value":"en_US"},{"label":"dc.publisher","value":"The Graduate School, Stony Brook University: Stony Brook, NY."},{"label":"dcterms.abstract","value":"Over the past decades, chemotherapy has transitioned to an age of \n\"targeted therapy.\" The development of Gleevec (Novartis) and Tarceva (Genentech \nand OSI Pharmaceuticals) has revolutionized the treatment of certain cancers, such as chronic \nmyelogenous leukemia (CML), non-small cell lung cancer (NSCLC) and pancreatic cancer. Gleevec \nspecifically targets the cancer cell-overexpressed Abl tyrosine kinase, and Tarceva targets \nthe epidermal growth factor receptor that is mutated in different types of cancers. However, \nthe use of these modern targeted-therapies is limited to specific cancer types. Therefore, \nconsiderable efforts have been made to find cancer-specific markers which can be exploited \nfor tumor-specific delivery of more traditional chemotherapeutic drugs. A promising approach \nalong this line is the development of tumor-targeting drug conjugates, which consists of one \nor multiple cytotoxic drugs (warheads) connected to a tumor-targeting module (TTM) via \ncleavable covalent bonds or cleavable linkers. The drug conjugates have been designed to \nremain inactive until they are specifically delivered to the tumor site, guided by the TTM \nand internalized, where the warhead is released from the carrier, restoring its original \nactivity. New-generation taxoids have been developed by the Ojima laboratory via the \n\u0392-lactam synthon method. These taxoids show orders of magnitude greater potency in a \nnumber of cancer cell lines compared to the parent compound paclitaxel. Thus, new-generation \ntaxoids are promising candidates as warheads for tumor-targeting drug conjugates. \nAccordingly, a number of new-generation taxoid-based drug conjugates have been developed that \ncontain polyunsaturated fatty acids (PUFAs), vitamins and monoclonal antibodies (mAbs) as \nTTM. The synthesis and biological evaluation of these novel drug conjugates will be \ndiscussed."},{"label":"dcterms.available","value":"2013-05-22T17:35:56Z"},{"label":"dcterms.contributor","value":"Ojima, Iwao"},{"label":"dcterms.creator","value":"Zuniga, Edison S."},{"label":"dcterms.dateAccepted","value":"2013-05-22T17:35:56Z"},{"label":"dcterms.dateSubmitted","value":"2015-04-24T14:47:42Z"},{"label":"dcterms.description","value":"Department of \nChemistry"},{"label":"dcterms.extent","value":"432 pg."},{"label":"dcterms.format","value":"Application/PDF"},{"label":"dcterms.identifier","value":"http://hdl.handle.net/1951/59941"},{"label":"dcterms.issued","value":"2012-05-01"},{"label":"dcterms.language","value":"en_US"},{"label":"dcterms.provenance","value":"Made available in DSpace on 2013-05-22T17:35:56Z (GMT). No. of bitstreams: 1\nZuniga_grad.sunysb_0771E_10892.pdf: 25940796 bytes, checksum: 7008d78ad7f564fb4aae12b1ea892b8d (MD5)\n  Previous issue date:    1"},{"label":"dcterms.publisher","value":"The Graduate School, Stony Brook University: Stony Brook, NY."},{"label":"dcterms.subject","value":"Anticancer agent, Cytotoxicity, Drug conjugate, Taxoid, Tumor-targeted drug \ndelivery"},{"label":"dcterms.title","value":"Design, synthesis and biological \nevaluation of new-generation taxoid-based tumor-targeting drug conjugates"},{"label":"dcterms.type","value":"Dissertation"},{"label":"dc.type","value":"Dissertation"}],"description":"This manifest was generated dynamically","viewingDirection":"left-to-right","sequences":[{"@type":"sc:Sequence","canvases":[{"@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/canvas/page-1.json","@type":"sc:Canvas","label":"Page 1","height":1650,"width":1275,"images":[{"@type":"oa:Annotation","motivation":"sc:painting","resource":{"@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/42%2F42%2F77%2F42427762860272304809972118768146424964/full/full/0/default.jpg","@type":"dctypes:Image","format":"image/jpeg","height":1650,"width":1275,"service":{"@context":"http://iiif.io/api/image/2/context.json","@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/42%2F42%2F77%2F42427762860272304809972118768146424964","profile":"http://iiif.io/api/image/2/level2.json"}},"on":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/canvas/page-1.json"}]}]}]}