{"@context":"http://iiif.io/api/presentation/2/context.json","@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/manifest.json","@type":"sc:Manifest","label":"A New Approach to the Synthesis of the Bicyclic Core of the Immunosuppressants SNF4435 C & SNF4435 D via Silicon Tethering","metadata":[{"label":"dc.description.sponsorship","value":"This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree."},{"label":"dc.format","value":"Monograph"},{"label":"dc.format.medium","value":"Electronic Resource"},{"label":"dc.identifier.uri","value":"http://hdl.handle.net/11401/71202"},{"label":"dc.language.iso","value":"en_US"},{"label":"dc.publisher","value":"The Graduate School, Stony Brook University: Stony Brook, NY."},{"label":"dcterms.abstract","value":"The total synthesis of immunosuppressant and multidrug resistant (MDR) reversal agents SNF4435 C and SNF4435 D, isolated from the culture broth of an Okinawan strain of Streptomyces spectabilis in 2001, has been accomplished in a fourteen step process. The key reaction utilizes a Stille coupling en route to the final products. Considering the limitations of the Stille coupling, we are currently adjusting the procedure to allow for a new approach, which involves the use of a molecular tether to join the two precursor molecules. This thesis describes the synthesis of a new pair of precursors as well as our efforts toward linking said molecules together via an appropriate silicon bridge."},{"label":"dcterms.available","value":"2015-04-24T14:46:29Z"},{"label":"dcterms.contributor","value":"Parker, Kathlyn A"},{"label":"dcterms.creator","value":"Dick, Andrew Daniel"},{"label":"dcterms.dateAccepted","value":"2013-05-22T17:34:24Z"},{"label":"dcterms.dateSubmitted","value":"2015-04-24T14:46:29Z"},{"label":"dcterms.description","value":"Department of Chemistry"},{"label":"dcterms.extent","value":"40 pg."},{"label":"dcterms.format","value":"Monograph"},{"label":"dcterms.identifier","value":"http://hdl.handle.net/11401/71202"},{"label":"dcterms.issued","value":"2012-12-01"},{"label":"dcterms.language","value":"en_US"},{"label":"dcterms.provenance","value":"Made available in DSpace on 2013-05-22T17:34:24Z (GMT). No. of bitstreams: 1\nDick_grad.sunysb_0771M_11232.pdf: 774755 bytes, checksum: 64615b9be30f9636311a8db94317b93f (MD5)\n  Previous issue date:    1"},{"label":"dcterms.publisher","value":"The Graduate School, Stony Brook University: Stony Brook, NY."},{"label":"dcterms.subject","value":"Organic chemistry"},{"label":"dcterms.title","value":"A New Approach to the Synthesis of the Bicyclic Core of the Immunosuppressants SNF4435 C & SNF4435 D via Silicon Tethering"},{"label":"dcterms.type","value":"Thesis"},{"label":"dc.type","value":"Thesis"}],"description":"This manifest was generated dynamically","viewingDirection":"left-to-right","sequences":[{"@type":"sc:Sequence","canvases":[{"@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/canvas/page-1.json","@type":"sc:Canvas","label":"Page 1","height":1650,"width":1275,"images":[{"@type":"oa:Annotation","motivation":"sc:painting","resource":{"@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/15%2F81%2F62%2F158162741409699050272688417442076194087/full/full/0/default.jpg","@type":"dctypes:Image","format":"image/jpeg","height":1650,"width":1275,"service":{"@context":"http://iiif.io/api/image/2/context.json","@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/15%2F81%2F62%2F158162741409699050272688417442076194087","profile":"http://iiif.io/api/image/2/level2.json"}},"on":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/canvas/page-1.json"}]}]}]}