{"@context":"http://iiif.io/api/presentation/2/context.json","@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/manifest.json","@type":"sc:Manifest","label":"The Specificity of Vesicle Trafficking during Prospore Membrane Formation in Yeast","metadata":[{"label":"dc.description.sponsorship","value":"This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree."},{"label":"dc.format","value":"Monograph"},{"label":"dc.format.medium","value":"Electronic Resource"},{"label":"dc.identifier.uri","value":"http://hdl.handle.net/1951/55680"},{"label":"dc.language.iso","value":"en_US"},{"label":"dc.publisher","value":"The Graduate School, Stony Brook University: Stony Brook, NY."},{"label":"dcterms.abstract","value":"This research focuses on the production of new plasma membranes during gametogenesis in yeast. The initiation of these membranes is started by vesicle fusion at spindle pole bodies (SPBs) during Meiosis II. I have asked how these vesicles specifically fuse at SPBs but not at other locations, and demonstrated that binding interactions between soluble NSF attachment protein receptors (SNAREs) confer one layer of specificity to vesicle fusion at SPBs. Furthermore, I showed that SPBs can actively regulate a Rab GTPase, suggesting a role for SPBs in vesicle docking. My work highlights the ancestral dual roles of centrioles in microtubule organization and membrane nucleation, the latter of which is required for cilium formation in mammalian cells."},{"label":"dcterms.available","value":"2012-05-15T18:07:24Z"},{"label":"dcterms.contributor","value":"Nancy Hollingsworth"},{"label":"dcterms.creator","value":"Yang, Hui-Ju"},{"label":"dcterms.dateAccepted","value":"2012-05-15T18:07:24Z"},{"label":"dcterms.dateSubmitted","value":"2015-04-24T14:45:03Z"},{"label":"dcterms.description","value":"Department of Molecular and Cellular Biology"},{"label":"dcterms.format","value":"Monograph"},{"label":"dcterms.identifier","value":"http://hdl.handle.net/1951/55680"},{"label":"dcterms.issued","value":"2010-12-01"},{"label":"dcterms.language","value":"en_US"},{"label":"dcterms.provenance","value":"Made available in DSpace on 2012-05-15T18:07:24Z (GMT). No. of bitstreams: 1\nYang_grad.sunysb_0771E_10372.pdf: 7307739 bytes, checksum: 8279af916a9603164fb435e5aabca166 (MD5)\n  Previous issue date:    1"},{"label":"dcterms.publisher","value":"The Graduate School, Stony Brook University: Stony Brook, NY."},{"label":"dcterms.subject","value":"centriole, prospore membrane, Sec2, SNARE, spindle pole body"},{"label":"dcterms.title","value":"The Specificity of Vesicle Trafficking during Prospore Membrane Formation in Yeast"},{"label":"dcterms.type","value":"Dissertation"},{"label":"dc.type","value":"Dissertation"}],"description":"This manifest was generated dynamically","viewingDirection":"left-to-right","sequences":[{"@type":"sc:Sequence","canvases":[{"@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/canvas/page-1.json","@type":"sc:Canvas","label":"Page 1","height":1650,"width":1275,"images":[{"@type":"oa:Annotation","motivation":"sc:painting","resource":{"@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/11%2F37%2F63%2F113763110578777928309583919404491075066/full/full/0/default.jpg","@type":"dctypes:Image","format":"image/jpeg","height":1650,"width":1275,"service":{"@context":"http://iiif.io/api/image/2/context.json","@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/11%2F37%2F63%2F113763110578777928309583919404491075066","profile":"http://iiif.io/api/image/2/level2.json"}},"on":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/canvas/page-1.json"}]}]}]}