{"@context":"http://iiif.io/api/presentation/2/context.json","@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/manifest.json","@type":"sc:Manifest","label":"Characterizing the lipoproteins LprG and LprA towards a better understanding of lipid transport mechanisms in Mycobacterium tuberculosis","metadata":[{"label":"dc.description.sponsorship","value":"This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree."},{"label":"dc.format","value":"Monograph"},{"label":"dc.format.medium","value":"Electronic Resource"},{"label":"dc.identifier.uri","value":"http://hdl.handle.net/11401/77086"},{"label":"dc.language.iso","value":"en_US"},{"label":"dc.publisher","value":"The Graduate School, Stony Brook University: Stony Brook, NY."},{"label":"dcterms.abstract","value":"Two lipoproteins, MtbLprG and MtbLprA, have been characterized as TLR2 agonists. Knockout of the lprG operon (lprG-rv1410c) results in decreased virulence of M. tb. While their importance for host-pathogen interactions has been the subject of numerous studies, the physiological functions of LprG and LprA are not known. We present here data towards elucidating the physiological functions of LprG and LprA, both in M. tb and M. smegmatis, including localization, binding affinity to respective ligands, as well as the phenotype of knockout strains, which will contribute a model for lipid transport through the cell wall."},{"label":"dcterms.available","value":"2017-09-20T16:51:55Z"},{"label":"dcterms.contributor","value":"Tonge, Peter"},{"label":"dcterms.creator","value":"Bai, Lu"},{"label":"dcterms.dateAccepted","value":"2017-09-20T16:51:55Z"},{"label":"dcterms.dateSubmitted","value":"2017-09-20T16:51:55Z"},{"label":"dcterms.description","value":"Department of Chemistry."},{"label":"dcterms.extent","value":"46 pg."},{"label":"dcterms.format","value":"Application/PDF"},{"label":"dcterms.identifier","value":"http://hdl.handle.net/11401/77086"},{"label":"dcterms.issued","value":"2013-12-01"},{"label":"dcterms.language","value":"en_US"},{"label":"dcterms.provenance","value":"Made available in DSpace on 2017-09-20T16:51:55Z (GMT). No. of bitstreams: 1\nBai_grad.sunysb_0771M_11555.pdf: 4026830 bytes, checksum: 5a2b41bd984e314c85b8c3269ca469c1 (MD5)\n  Previous issue date:    1"},{"label":"dcterms.publisher","value":"The Graduate School, Stony Brook University: Stony Brook, NY."},{"label":"dcterms.subject","value":"Chemistry"},{"label":"dcterms.title","value":"Characterizing the lipoproteins LprG and LprA towards a better understanding of lipid transport mechanisms in Mycobacterium tuberculosis"},{"label":"dcterms.type","value":"Thesis"},{"label":"dc.type","value":"Thesis"}],"description":"This manifest was generated dynamically","viewingDirection":"left-to-right","sequences":[{"@type":"sc:Sequence","canvases":[{"@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/canvas/page-1.json","@type":"sc:Canvas","label":"Page 1","height":1650,"width":1275,"images":[{"@type":"oa:Annotation","motivation":"sc:painting","resource":{"@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/16%2F86%2F95%2F168695927441129107500685959113678312795/full/full/0/default.jpg","@type":"dctypes:Image","format":"image/jpeg","height":1650,"width":1275,"service":{"@context":"http://iiif.io/api/image/2/context.json","@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/16%2F86%2F95%2F168695927441129107500685959113678312795","profile":"http://iiif.io/api/image/2/level2.json"}},"on":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/canvas/page-1.json"}]}]}]}