{"@context":"http://iiif.io/api/presentation/2/context.json","@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/manifest.json","@type":"sc:Manifest","label":"An initial analysis of the role of Sts-1 and Sts-2 in the development of regulatory T cells","metadata":[{"label":"dc.description.sponsorship","value":"This work is sponsored by the Stony Brook University Graduate School in compliance with the requirements for completion of degree."},{"label":"dc.format","value":"Monograph"},{"label":"dc.format.medium","value":"Electronic Resource"},{"label":"dc.identifier.uri","value":"http://hdl.handle.net/11401/71413"},{"label":"dc.language.iso","value":"en_US"},{"label":"dc.publisher","value":"The Graduate School, Stony Brook University: Stony Brook, NY."},{"label":"dcterms.abstract","value":"Regulatory T cells (Tregs) play a critical role in down-regulating immune responses to self antigens. Here we assess the significance of Sts-1 and Sts-2, two protein phosphatases that negatively regulate TCR signaling, in the development and maintenance of Tregs. We show that the number of splenic Tregs in vivo is elevated in the absence of Sts-1and Sts-2. We also found that Sts-1 and Sts-2 play a redundant role in TGF--mediated induction of Tregs in vitro. These data indicate that the Sts proteins are crucial for the maintenance of normal Treg populations in mice and also in TGF--mediated induction of Tregs in vitro."},{"label":"dcterms.available","value":"2015-04-24T14:47:28Z"},{"label":"dcterms.contributor","value":"Reich, Nancy."},{"label":"dcterms.creator","value":"Sivaram, Nithya"},{"label":"dcterms.dateAccepted","value":"2013-05-22T17:35:36Z"},{"label":"dcterms.dateSubmitted","value":"2015-04-24T14:47:28Z"},{"label":"dcterms.description","value":"Department of Biochemistry and Cell Biology"},{"label":"dcterms.extent","value":"30 pg."},{"label":"dcterms.format","value":"Application/PDF"},{"label":"dcterms.identifier","value":"http://hdl.handle.net/1951/59864"},{"label":"dcterms.issued","value":"2011-12-01"},{"label":"dcterms.language","value":"en_US"},{"label":"dcterms.provenance","value":"Made available in DSpace on 2015-04-24T14:47:28Z (GMT). No. of bitstreams: 3\nSivaram_grad.sunysb_0771M_10815.pdf.jpg: 1894 bytes, checksum: a6009c46e6ec8251b348085684cba80d (MD5)\nSivaram_grad.sunysb_0771M_10815.pdf.txt: 42896 bytes, checksum: b9b04e360a49eb1449de3e37b6607275 (MD5)\nSivaram_grad.sunysb_0771M_10815.pdf: 1406818 bytes, checksum: 3998f71af08eb5a7f5e31422a184d78c (MD5)\n  Previous issue date:    1"},{"label":"dcterms.publisher","value":"The Graduate School, Stony Brook University: Stony Brook, NY."},{"label":"dcterms.subject","value":"Immunology--Biochemistry"},{"label":"dcterms.title","value":"An initial analysis of the role of Sts-1 and Sts-2 in the development of regulatory T cells"},{"label":"dcterms.type","value":"Thesis"},{"label":"dc.type","value":"Thesis"}],"description":"This manifest was generated dynamically","viewingDirection":"left-to-right","sequences":[{"@type":"sc:Sequence","canvases":[{"@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/canvas/page-1.json","@type":"sc:Canvas","label":"Page 1","height":1650,"width":1275,"images":[{"@type":"oa:Annotation","motivation":"sc:painting","resource":{"@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/24%2F89%2F26%2F24892643011773991783499630206096183059/full/full/0/default.jpg","@type":"dctypes:Image","format":"image/jpeg","height":1650,"width":1275,"service":{"@context":"http://iiif.io/api/image/2/context.json","@id":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/24%2F89%2F26%2F24892643011773991783499630206096183059","profile":"http://iiif.io/api/image/2/level2.json"}},"on":"https://repo.library.stonybrook.edu/cantaloupe/iiif/2/canvas/page-1.json"}]}]}]}